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New Defender's Study Bible Notes
53:3 we hid. Just as Adam and Eve tried to hide from God (Genesis 3:8), so we try to hide our rebellious ways from Christ.
53:3 esteemed him not. Literally, “we estimated Him as nothing”—the typical reaction of the world to Jesus Christ as our suffering substitute.
53:4 our griefs. “Griefs” means “sicknesses” (Matthew 8:17). All sickness and pain is ultimately the result of sin, especially the fatal sickness of death itself. By His death, all pain and sickness and death will finally be removed forever (Revelation 21:4, 5).
53:5 wounded. This phrase means literally, “thrust through,” as with a spear, or spikes, speaking of crucifixion.
53:5 bruised. This phrase means literally, “crushed,” as to death. Compare Genesis 3:15.
53:6 hath laid on him. This means literally, “laid on with a death-dealing blow,” as He died both for the sin of the world and our individual sins (note John 1:29; Romans 5:12).