2:25 David speaketh. At this point in his sermon, Peter makes an extended quotation from the sixteenth psalm, quoting Psalm 16:8-11 (in Acts 2:25-27) of this remarkable Messianic psalm, which predicts the Gethsemane prayer; then the trial, death, burial, resurrection and ascension of Christ a thousand years before the fulfillment. See notes on Psalm 16.

2:26 my flesh. This was a prophetic glimpse of His brief “rest” in Joseph’s tomb, prior to His returning incorruptible from hell (i.e., hades).

2:27 not leave my soul in hell. This remarkable prophecy of Messiah’s resurrection was not fulfilled by David, as Peter said (Acts 2:29). In fact, Peter and the other disciples could not even understand Jesus’ straightforward promises of His coming death and resurrection, let alone the Messianic prophecies of the Old Testament. But when the event finally occurred, and the Holy Spirit came to indwell and teach them, Peter and the others became powerful expositors of the Scriptures, especially of the Messianic prophecies.