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New Defender's Study Bible Notes
53:4 our griefs. “Griefs” means “sicknesses” (Matthew 8:17). All sickness and pain is ultimately the result of sin, especially the fatal sickness of death itself. By His death, all pain and sickness and death will finally be removed forever (Revelation 21:4, 5).
53:6 hath laid on him. This means literally, “laid on with a death-dealing blow,” as He died both for the sin of the world and our individual sins (note John 1:29; Romans 5:12).