2:16 profane. That is, “ungodly” or “unholy.”

2:16 vain babblings. See I Timothy 6:20, where Paul identifies “profane and vain babblings” as related to “science falsely so called,” referring essentially to pantheistic evolutionary philosophy.

2:17 canker. This could be an ulcer or any ulcerating sore, even a cancer.

2:17 Hymenaeus and Philetus. Hymenaeus means “singing man” and Philetus means “friendly man.” These names may well suggest the characters of these two blasphemers (see note on I Timothy 1:20). It is often true that the most effective subverters of God’s Word of truth are men who outwardly seem to be very smooth and charming (compare II Corinthians 11:13-15).